The Baltimore Orioles and Boston Red Sox will hope to avoid any more weather delays when they meet in the second game of the series and first of a doubleheader on Saturday. Thursday's series-opener was rained out and they managed to just get in one game on Friday, a 19-5 Red Sox win. Zach Eflin (3-2, 5.08 ERA) is starting for Baltimore, while Hunter Dobbins (2-1, 3.62 ERA) is on the hill for Boston.
First pitch from Fenway Park in Boston is set for 1:05 p.m. ET. Boston is -115 on the money line (risk $115 to win $100) in the latest Orioles vs. Red Sox odds from FanDuel Sportsbook, while the over/under for total runs scored is 9. Before making any Orioles vs. Red Sox picks, be sure to see the MLB predictions from SportsLine's proven model. You can also see the best Saturday MLB home run picks.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 9 of the 2025 MLB season on a 13-8 run (62%) on top-rated MLB money-line betting picks. Anybody following at sportsbooks and on betting apps, or new users taking advantage of the latest DraftKings promo code or Fanatics Sportsbook promo code could have seen strong returns.
Here are the model's three best bets for Orioles vs. Red Sox on Saturday:
- Red Sox ML (-115)
- Over 9 runs (-120)
- Hunter Dobbins Over 4.5 strikeouts (+105)
Red Sox to win (-115)
Boston has dominated the series of late, winning five of the last seven meetings. The Orioles (16-33), who are just 1-9 over the past 10 games, are 8-18 on the road this season. The Red Sox (26-26), who are tied for second in the American League East, are 15-12 on their home field. Rafael Devers had a monster game against Baltimore on Friday, going 4-for-6 with two homers and eight RBI with three runs scored. FanDuel Sportsbook has the Red Sox winning at -112.
If you want even more MLB picks, SportsLine's top MLB expert, Matt Severance, is heating up. Get his best bets for Thursday, all from the expert who is 121-61 on his last 182 MLB picks (+18).
Over 9 total runs (-120)
The model originally backed the Under at 9.5, but the line movement down to 9 makes the Over the better play. Baltimore has gone Over in his of its last six games, and these teams combined for a whopping 24 runs in Game 1 of this series on Friday, easily clearing the total in that game. The model is projecting 9.9 combined runs, making that the value play.
You've now seen two best bets for Orioles vs. Red Sox in the first game of a doubleheader on Saturday. Now, get picks for every single game from the model that enters Week 9 of the 2025 MLB season on a 13-8 run (62%) on top-rated MLB run-line picks.
Hunter Dobbins over 4.5 strikeouts (+105)
Right-hander Hunter Dobbins has made six starts this season and has recorded 25 strikeouts in 32.1 innings of work. In a 2-1 loss at Kansas City on May 9, he received a no-decision after pitching six solid innings, allowing five hits, no earned runs and no walks, while striking out six. He also struck out six batters in a 10-3 win over the Chicago White Sox on April 18. He struck out five in an 18-7 win over St. Louis on April 6. DraftKings Sportsbook has this prop at +105.
